Single-Cell Analysis: The Differences That Kill
نویسنده
چکیده
Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.
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ورودعنوان ژورنال:
- Cell
دوره 162 شماره
صفحات -
تاریخ انتشار 2015